2024

Reynolds LM, Gulmez A, Fayad SL,  Costa Campos R, Rigoni D, Nguyen C, Le Borgne T, Topilko T, Rajot D, Franco C, Fernandez SP, Marti F, Heck N, Mourot A, Renier N, Barik J, Faure P. Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state. Nature Comunnications 2024 (here)

2022

Broussot L*, Contesse T* (*equal contribution), Costa-Campos R, Glangetas C, Royon L, Fofo H, Lorivel T, Georges F, Fernandez SP and Barik J (co-last authors).  A non-canonical GABAergic pathway to the VTA promotes unconditioned freezing . Molecular Psychiatry 2022 (here).

Ortiz V*, Costa-Campos R* (*equal contribution), Fofo H, Fernandez SP, Barik J. Nicotinic receptors promote susceptibility to social stress in female mice linked with neuroadaptations within midbrain VTA dopamine neurons. Neuropsychopharmacology 2022 (here) 

Research highlight :https://www.nature.com/articles/s41386-022-01330-4

2021

Contesse T, Broussot L, Fofo H, Vanhoutte P, Fernandez SP*, Barik J* (*equal contribution).  Dopamine and glutamate receptors control social stress-induced striatal ERK1/2 activation. Neuropharmacology 2021 (here) 

Bermudez-Martin P, Becker JAJ, Caramello N, Fernandez SP, Costa-Campos R, Canaguier J, Barbosa S, Martinez-Gili L, Myridakis A, Dumas ME, Bruneau A, Cherbuy C, Langella P, Callebert J, Launay JM, Chabry J, Barik J, Le Merrer J, Glaichenhaus N, Davidovic L. The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome 2021

Andrianarivelo A, Saint-Jour E, Pousinha P, Fernandez SP, Petitbon A, De Smedt-Peyrusse V, Heck N, Ortiz V, Allichon MC, Kappès V, Betuing S, Walle R, Zhu Y, Joséphine C, Bemelmans AP, Turecki G, Mechawar N, Javitch JA, Caboche J, Trifilieff P, Barik J, Vanhoutte P. Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing. Science Advances 2021 

2019

Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H. The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding. Cell Reports 2019 

2018

Fernandez SP*, Broussot L, Marti F, Contesse T, Mouska X, Soiza-Reilly M, Marie H, Faure P, Barik J*. Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors. Nature Communications 2018 (here)

We uncovered a circuit mechanism relevant to depression. The work helped identify molecular candidates and brain regions that can be targeted for developing novel therapies. See press release from Nice Matin and Societe des Neurosciences

Morel C*, Fernandez SP* (*equal contribution) , Pantouli F, Meye FJ, Marti F, Tolu S, Parnaudeau S, Marie H, Tronche F, Maskos U, Moretti M, Gotti C, Han MH, Bailey A, Mameli M, Barik J, Faure P. Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity. Molecular Psychiatry 2017 (here)

​Belmer A, Quentin E, Diaz SL, Guiard BP, Fernandez SP, Doly S, Banas SM, Pitychoutis PM, Moutkine I, Muzerelle A, Tchenio A, Roumier A, Mameli M, Maroteaux L. Positive regulation of raphe serotonin neurons by serotonin 2B receptors. Neuropsychopharmacology 2018 

2017

Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-García JM, Gaspar P. Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity. Neuropsychopharmacology 2017

Doly S, Quentin E, Eddine R, Tolu S, Fernandez SP, Bertran-Gonzalez J, Valjent E, Belmer A, Viñals X, Callebert J, Faure P, Meye FJ, Hervé D, Robledo P, Mameli M, Launay JM, Maldonado R, Maroteaux L. Serotonin 2B Receptors in Mesoaccumbens Dopamine Pathway Regulate Cocaine Responses. Journal of Neuroscience 2017 

2016

Fernandez SP, Cauli B, Cabezas C, Muzerelle A, Poncer JC, Gaspar P*. Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain. Brain Structure and Function 2016  

2013​

Kiyasova V, Bonnavion P, Scotto-Lomassese S, Fabre V, Sahly I, Tronche F, Deneris E, Gaspar P, Fernandez SP*. A subpopulation of serotonergic neurons that do not express the 5-HT1A autoreceptor. ACS Chem. Neurosci 2013

Barik J, Marti F, Morel C, Fernandez SP, Lanteri C, Godeheu G, Tassin JP, Mombereau C, Faure P, Tronche F. Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons. Science 2013

2012

Diaz SL, Doly S, Narboux-Neme N, Fernandez S, Mazot P, Banas SM, Boutourlinsky K, Moutkine I, Belmer A, Roumier A, Maroteaux L. 5-HT2B receptors are required for serotonin-selective antidepressant actions. Molecular Psychiatry 2012 

Fernandez SP, Karim N, Mewett KN, Pasricha A, Chebib M, Johnston GAR, Hanrahan JR. Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology 2012 

2011

Kiyasova V*, Fernandez SP* (*equal contribution), Laine J, Stankovski1 L, Muzerelle A, Doly S, Gaspar P. A genetically-defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei. Journal of Neuroscience 2011

2009

Fernandez SP, Nguyen M, Yow TT, Chu C, Johnston GA, Hanrahan JR, Chebib M. The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochem Res 2009 

Martínez MC, Fernandez SP, Loscalzo LM, Wasowski C, Paladini AC, Marder M, Medina JH, Viola H. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacol Biochem Behav 2009

2008

Fernandez SP, Mewett KN, Hanrahan JR, Chebib M, Johnston GAR. Flavan-3-ol derivatives are positive modulators of GABAA receptors with higher efficacy for the α2 subtype and anxiolytic action in mice. Neuropharmacology 2008​

2006​

Fernandez SP, Wasowski C, Loscalzo LM, Granger RE, Johnston GAR, Paladini AC, Marder M. Central nervous system depressant action of flavonoid glycosides. Eur J Pharmacol 2006

​2005

Fernandez SP, Wasowski C, Paladini AC, Marder M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur J Pharmacol 2005

​2004

Fernandez SP, Wasowski C, Paladini AC, Marder M. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacol Biochem Behav 2004

​2003

Marder M, Viola H, Wasowski C, Fernandez S, Medina JH, Paladini AC. 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS. Pharmacol Biochem Behav 2003

Book Chapters and Reviews

• Fernandez SP and Gaspar P. Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion. Neuropharmacology 2012

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• Johnston GAR, Chebib M, Duke RK, Fernandez SP, Hanrahan JR, Hinton T, Mewett KN. Herbal products and GABA receptors. In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2008.